Photo: Courtesy of ABC

According to Michael Ausiello, hardworking, recently untumored Grey's Anatomy star Katherine Heigl will take a five-episode break from the show this season to shoot Life As We Know It, a terrific-sounding romantic comedy in which her character inherits two kids from friends who die in an accident. So which hilarious excuse will famously vengeful Grey's creator Shonda Rhimes use to explain Izzie's hiatus? A coma? A stint in prison? Perhaps her cancer can return and she can be cryogenically frozen until doctors discover a cure five weeks later? [Ausiello Files/EW]