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Founded by Nicholas Acquavella in 1925, this tony, family-run Upper East Side gallery is now directed by his son, William and grandchildren Eleanor, Nicholas and Alexander. Every spring, the gallery hosts a large, two-story group show (think Picasso, Matisse, Rauschenberg); otherwise, only the first floor of the five-story building is open to the public. During the rest of the year, visitors can view a random sampling of the gallery’s huge, museum-worthy collection, which includes sculptures and paintings by nearly all of the 19th and 20th century biggies—from Bacon to Basquiat to Brancusi. Expect a crowd of museum-hoppers (at 79th and Fifth, it's a perfect pit stop between the Whitney and the Met), tourists, rival dealers and the lucky, lucky few who are actually in the market for a Monet. — Steffani Jemison