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Andrew W.K., the late-nineties-party-starter turned record-producer/motivational-speaker/general-jack-of-all-trades, is only one of the owners of Santos Party House, but his playful spirit pervades the place. The bi-level club packs a fierce 150,000 watt sound system, and lets almost nothing get in the way of that wondrous noise: both the upstairs and the smaller downstairs levels come equipped with little more than stages, disco balls, black-paint, and silly, happy slogans ("Thank you for partying!” "You have a beautiful face!”) Almost nightly, the place plays host to a fevered, wonderfully diverse batch of high-energy performers and DJs, whether it’s the Que Bajo party kicking out the choicest Latin American party jams or Mr. W.K. himself on the decks or on the mic. — Amos Barshad

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