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Former cosmetology instructor Sunny Moon opened this nail and skincare spa in 1997, naming it after her favorite card game, blackjack. The intimate, unadorned space is the smaller of her two spas—Moon also owns the full-service Spa Meridian in Midtown—and she fosters a homey vibe by offering tea and lotus cakes to customers before services. Regulars from the nearby Natural History Museum and neighborhood walk-ins return for the intensive Scruffin mani/pedi ($90), which incorporates Bodipure’s exfoliant scrubs of baking soda, green tea, and peppermint oil to slough off dry skin on calves and heels and includes a fifteen minute massage. But the real draw are the tech-savvy 90-minute facials, using the Dermalogica skincare line. Twenty One’s estheticians are trained at the line’s local Derma Institute, receiving additional refresher courses when new products are released. Each facial offers cleansing, exfoliating, moisturizing, and toning components, including customized extras like oil-controlling serums, hydrating multi-vitamin-enriched masks, and skin tightening. Prices range from an abbreviated mini-facial ($50) to the popular anti-aging and intensive hydrating-therapy facials ($120). — Rachel Aydt