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Sure, the Chambers is boutique hotel-chic, but its very "Brady Bunch" lobby staircase—complete with an under-stair seating area—may have arrivals humming a certain infectious theme song. Thankfully, the cool Brazilian music pumping from the speakers and stylish mezzanine-level bar will snap guests out of any momentary Nick-at-Nite flashbacks. Glass-walled elevators stop at 15 uniquely decorated floors, each featuring hotel-commissioned artwork from the likes of John Waters and Do-Ho Suh. The spacious and stylish guest rooms resemble artists' lofts, albeit modern, high-tech ones; enormous windows and shelves packed with glossy art and film books co-mingle with flat-screen TVs, yoga cards and one-touch dialing to Henri Bendel and Exhale Spa. The color palette is classic and neutral, with touches of vibrant color and texture scattered throughout; the beautiful tiled bathrooms feature soaking tubs or rainwater-head showers. Guests are guaranteed that at least five of the hotel's 500 original works will adorn their suites—none, thankfully, by Florence Henderson. — Nick Divito

Luxurious, comfortable, conveniently located and hip.

Cons
While chic, the lobby feels a little cold and uninviting.