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From its stylish staff to the dark African wood that shapes its custom designed furniture, this sleek, postmodern confection of a hotel makes a preferred resting spot for celebrities, models and movie stars. All 75 of the hotel’s rooms and suites are lofts filled with Christian Liaigre interiors, utilizing the streamlined look to near extremes. Faced with its supple leathers, rich wooden floors and crisp linens, guests might not want to leave their rooms; a glimpse of the oversized showers, two-person bathtubs, and complimentary toiletries from Swedish cosmetic company FACE and guests may not even leave the opulent bathrooms. Grab a snack from the Dean & Deluca stocked mini-bar, or opt for a more substantial meal at A-list favorite Mercer Kitchen, starring famed Jean-Georges Vongerichten's French/Asian Fusion fare. After dinner, feel free to enjoy a post-meal workout at the nearby Equinox gym—on the house. — Sarah Niersbach

The Mercer offers more amenities than a guest could possibly know what to do with, from plasma screen TV and DVDs to private trainers to packing and unpacking services and beyond.

Cons
The unstylish might feel rather out of place among the celebrities and scenesters who favor this Soho hotel for its discretion.