Spend the night at the Town Hall Hotel & Apartments (from $188), a luxuriously renovated former municipal building in the once-gritty, now-trendy neighborhood of Bethnal Green. Reopened in March 2010, the Edwardian façade houses 98 spacious rooms and suites with smart modern furnishings, like Rare Architects' low-lying rocking chair. Whitechapel Gallery director Iwona Blazwick curates the hotel's art collection, which features East End artists.
Be among the first to stay at Trevor Gulliver and celebrity chef Fergus Henderson's entry into the world of hospitality at St. John Hotel (from $379) just off Leicester Square. Opening in January 2011, its fifteen rooms feature painted-wood walls and the morning aroma of Henderson's buttery breakfast bun, served only at the hotel's restaurant.
Sleep in a reclaimed-floorboard-paneled bed in one of three new designer suites at the Hoxton Hotel (from $46) in East London's Shoreditch neighborhood. The best of the three—a 150-square-meter bedroom by design collective Project Orange—features a glass-and-red-tile circular shower, a handmade quilt, and an upended trunk-cum-boudoir. The Hoxton operates like an airline: The earlier you book, the cheaper it is.