Unpack your bags at the splashiest new design-centric hotel in the city, The Charlee (from $220), where the smallest room is 500 square feet. Opened in December 2010, the property also houses a massive health club and spa and a rooftop pool.
Sleep around the corner from the trendy Parque Lleras district’s best clubs and restaurants at Art Hotel Medellín (from $120). Its 54 rooms sport interior brick walls that contrast with bright red chairs. The hotel is also home to a private cinema that frequently hosts film festivals and art-house flicks.
Retreat from the city center at the 24-room Hotel y Parque Ecológico Piedras Blancas Piedras Blancas (from $165), which sits in the forested mountains and can be conveniently reached by cable car. Bordering an ecological park, the property includes access to canoes, zip lines, fishing, hiking, and a butterfly farm.