Start your stay with a pint of Victory Hop Devil Ale at the Swann Lounge downstairs in the Four Seasons (from $295). Take advantage of the hotel's proximity to the Art Museum/Fairmont neighborhood to hit a bunch of microbrew hot spots like the Belgian Café and the Bishop's Collar.
Drop your bags in the stunning original lobby at the Radisson Plaza-Warwick (from $149), built in 1926, on your way to the hotel's Tavern 17. The “artisanal flights and bites” menu includes a dozen craft beers on tap.
Sleep in a refurbished nineteenth-century hardware store at the Penn’s View Hotel (from $149). The hotel’s Ristorante Panorama has a strong wine-by-the-glass program, but don’t miss Philly brews such as Tröegs Rugged Trail Nut Brown Ale on tap.