Control the ambiance at MOODs (from $140), where rooms feature adjustable lighting that spans the color spectrum and luxurious handmade beds by Swedish company Hästens. Opened in 2010, this design hotel sets itself apart with an emphasis on technology (there’s a mobile app you can download) as well as unique touches like a 24-hour bar and breakfast service, and complimentary 30-minute Thai massages if you stay more than three nights. Ask for Rooms 305 or 405 for the best views of the Vltava River, and definitely take the short walk to see the iconic Municipal House and Powder Tower in Republic Square.
Find respite from the busy streets surrounding Wenceslas Square at Hotel Yasmin (from $127), designed by Czech minimalist Barbora Skorpilová and housed in a landmark building that dates to the 1890s. Inside, its Zenlike rooms in varying shades of ivory are juxtaposed with black-tiled bathrooms and silver accents to provide a visual yin and yang. For a look at some of the city’s architecture, book a deluxe room on the sixth floor, where you can spot the spires of Powder Gate and Jindřišská Tower through skylights.
Spend less without giving up style at the Fusion Hotel (beds from $20; rooms from $100), where minimalist rooms feel like galleries with stark white walls and the occasional burst of color. Book Rooms 302, 402, or 502 for 180-degree views of the city, or splurge on the forthcoming Fusion penthouse (from $228; anticipated opening in February), which will feature a private terrace looking out toward Prague Castle and Old Town Square. In the evening, you can stop into the lobby’s Skype booth before having cocktails at 360˚, Europe’s first rotating bar, which turns into a dance spot on Fridays and Saturdays, when resident D.J.'s spin techno until the wee hours.