Book well in advance for the five-course, pan-Asian tasting menu ($43) at Sansho, where British chef Paul Day (formerly of Nobu London) serves small plates at communal tables. The locally sourced menu changes often, but signature dishes include soft-shell-crab sliders, a salad of pork belly and watermelon, and beef rendang that is stewed for twelve hours.
Spend a morning strolling the gardens in Letna Park before having breakfast or lunch at Bistro 8, a new retro-inspired café that feels like a slice of Americana in the emerging Holešovice district. Locals start their day with the breakfast special: fluffy pancakes, fruit over granola, and cappuccino ($3.50), but come noon, there are also soups made from scratch ($2), quiche ($2.50), and pork dumplings ($3.50) on the menu.
Snag a waterfront table on the Vltava River at Jazz Dock, a modernist, glass-walled space offering scenic views and nightly performances. Fill up on supper-club classics like baked Camembert ($5.50) and steak and potatoes ($9.50) before the second act of the night takes the stage around 10 p.m. and transforms the restaurant into a swanky jazz club.