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The Best Diaper Creams, According to Pediatricians and Dermatologists

Photo: Rae Russel/Getty Images

Your baby’s first diaper rash is a dreadful experience — seeing it spread all red and angry, making your poor little infant cranky while making you feel guilty, as if it were your fault. The reality, though, is that it doesn’t take much for a rash to begin. For starters, diapers aren’t ideal environments for flesh, particularly the thin skin of newborns: “Water and moisture occluded on the skin without a barrier is a powerful irritant,” explains Dr. Jennifer MacGregor, a dermatologist at Union Square Laser Dermatology in New York City. “It can get so bad that skin breaks down and gets raw.” Dr. Jennifer Gruen, a Westport, Connecticut, pediatrician and co-founder of Village Pediatrics adds, “Stool (especially diarrhea, which can be acidic) and urine (which has ammonia) held close to skin, as well as rubbing from the diaper, all cause rash.” And then there’s the fact that even the most attentive parents can’t be immediately on top of every single dirty diaper in those early days when babies can be pooping all day long.

The good news is that there are plenty of effective ways to avoid and treat this common ailment. Experts’ top tips: Change baby’s diaper often (and promptly), do plenty of diaper-free air time, stick to basic water wipes (and use sparingly to avoid additional irritation), and apply a generous, preventative coat of diaper cream with every change — not just when they develop redness. “The main purpose of a diaper cream is to act as a protectant and barrier,” explains Dr. Whitney Tan, a dermatologist at Tribeca Park Dermatology in New York City. So the point bears repeating: Apply diaper cream with each and every change; spending the extra few seconds on this step can save you a lot of time and pain in the long run.

But of course, the inevitable will likely still happen. And at this point, “once rash is present,” Tan says, you should “work to hydrate and soothe skin and continue to protect it from worsened injury.” When tended to properly, most diaper rashes improve within 72 hours. Tan says to look for healing products with a thick texture and zinc oxide and petrolatum as the main active ingredients, which “soothe and seal off the skin from further exposure to a harsh environment.” Here, Tan, Gruen, MacGregor, and three other dermatologists and pediatricians recommend the best options to have on hand. And as all of our experts stressed, if your baby’s rash doesn’t show improvement in a few days, make an appointment with your doctor.

The best overall diaper cream

There are a lot of chic-looking diaper creams these days — you can even get a $28 tube on Net-a-Porter — but three of our experts chose good ol’ Vaseline, or petroleum jelly, as the very best treatment of them all. (Note: We’re using the term “cream” broadly here, even though some of these products are more like ointments, and don’t have the consistency of a cream in the traditional sense.) “I have two young kids now and one has eczema, and the most important thing is to seal skin with a barrier that protects against moisture and other irritants,” MacGregor says. “I grease my kids with Vaseline from head to toe after baths and use a thick layer with every diaper change. It’s simple, inexpensive, and prevents problems before they begin.” As for MacGregor’s point about price: To give a comparison, a 13-ounce tub of Vaseline costs about $3.50, while a similar size of other favored ointments like A&D, mentioned below, will run you about $11. Tan also voted for this classic workhorse, noting that, because it’s pure petrolatum, there are “no potential allergens” and that it acts as both an “emollient and barrier to soothe and protect skin.” In addition to forming a seal that keeps moisture from a wet diaper out, it also “prevents bacteria and yeast from entering skin,” says Dr. Sonia Batra, a Santa Monica, California–based dermatologist and co-host of The Doctors TV Show. Which could lead to even more intense forms of diaper rash.

The best diaper creams for preventing rash

For daily diaper changes and mild rashes, A+D Ointment is a favorite of Dr. Edward Kulich, a pediatrician and founder of KidsHousecalls, a pediatric house call concierge practice. The formula combines skin-protecting petrolatum with lanolin, another ingredient that helps keep skin moisturized, along with cod liver oil, “which serves as a vehicle for vitamins A and D,” he explains. The blend, he says, “helps provide an excellent hydrophobic barrier to lock the moisture in the skin and prevent the caustic urine and stool enzymes from contact with the skin.” Gruen also recommends A+D for its versatility. “It can be used for everything,” she says, “from diaper rash to dry skin.”

Another solid option for everyday prevention, according to NYC dermatologist Dr. Dendy Engelman, is Cetaphil Diaper Cream. “It contains skin-soothing botanical oils to keep delicate skin hydrated and zinc oxide to keep it protected,” she says. “Apply on clean skin every time you change a diaper starting in the front and working your way to the back.” An added bonus: It contains calendula — if you find yourself in a position where the diaper rash has already occurred, this plant-based ingredient will help soothe baby’s irritation.

The best diaper creams for overnight and more intense rashes

Most diaper creams have somewhere around 10 percent zinc oxide, but Desitin Maximum Strength Original Zinc Oxide Paste contains a whopping 40 percent (which, according to the brand’s site, is the highest percentage you’ll find without a prescription). “Zinc oxide does wonders for helping create a barrier when there is a sensitive diaper rash and allowing the skin to heal itself,” Kulich explains. Because of its high zinc content, it’s also ideal for nighttime use, according to Engelman: “The 40 percent zinc oxide provides a great protective barrier to ensure skin stays protected throughout the night, trapping moisture within while repelling water, so skin doesn’t break down.” While most creams wear off overnight, you’ll still notice a layer of this cream on baby’s skin at the early-morning diaper change. (This also helps justify the expense — about $5 more than a similar-sized tub of A&D.)